It can help you with your rhyme flow and your beatbox

from Madvillain (Ft. Madlib & Quasimoto) – America's Most Blunted Lyrics on Rap Genius

Meaning

The supervillian gives a bit of advice. Cannabis is known to spark creativity, and rappers often smoke weed to get inspired.

While weed can help, so can a detox. MF has said before in interviews that he isn’t always a fan of smoking while he writes.

In a different interview, DOOM said that he would be by himself on a balcony smoking blunts while Madlib would be downstairs making beats. This was around the time they made Madvilliany, but this was not, however, during his writing process.

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