Now, this one's layered. Firstly, this is a nod to the origin of Spider-Man, who was bitten by a radioactive spider. Deadpool is in many ways the more deranged version of the web-shooting wall-crawler

Secondly, this line comes from the comics. The issue it's taken from is *Cable & Deadpool* #2, published in 2004. They started planning a *Deadpool* movie with Ryan Reynolds that same year as well, though it was always pushed back

Thirdly, Ryan Reynolds wanted to play Deadpool because he was mentioned in this very panel. He talked about this in an interview with *Latino Review* in 2009, back when he was up for the role in *X-Men Origins: Wolverine* (a movie we all want to forget):

>Ya, I love the character. I’ve always loved the character. I remember reading one of the Deadpool comic books, and somebody asked Deadpool what he looks like. And he said he looks like a cross between a Shar-Pei and Ryan Reynolds. And I was like, I really, really wanna play this guy at some point

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