Now up and at 'em it's on, I was raised to be strong
And mama told me be a thug, since the day I was born
Tupac loved his mama so much and he tried to thank her in every situation or song, and this is a simple way of saying that his mother, (and the streets), raised him to be a strong man, and enemies should be aware of that.
To help improve the meaning of these lyrics, visit "R U Still Down? (Remember Me)" by 2Pac Lyrics and leave a comment on the lyrics box