Dudes want beef so I give them mad cow

from VANguard – CHIEF Lyrics on Rap Genius

Meaning

A common way to gain recognition in the rap game now-a-days is to start a beef with higher profiled artist’s. However, a lot of artists end up biting off more than they can chew when it comes to hip hop rivalries, which Vanguard alludes to in this line.

Mad Cow refers to the disease transmitted through unknowingly eating tainted “beef”. This play on words comes full circle to connect with the previous line concerning the number “16” & “ounce”—the average size of a steak.

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