Tryna pitch, gotta run the base
He “pitches” (sells) cocaine (“base”). Bases are run in baseball to score points like cocaine is sold to make money.
This line is reminiscent of these infamous Jay-Z lines:
I father, I Brooklyn Dodger them
I jack, I rob, I sin;
Aw, man, I’m Jackie Robinson
‘Cept when I run base, I dodge the pen
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