To which I replied: "Are you sure?
Even the murderer? Even the whore?
Even the nigga running through bitches on tour?"

from J. Cole – Runaway Lyrics on Rap Genius

Meaning

He is questioning the idea that all humans are made in God’s image and gives some darker examples and asking if these are truly an image of the Lord. Is God really a murderer, whore, and a cheater?

It’s also Cole feeling bad because he’s the latter part of that bar “…nigga running through bitches on tour” He goes into who he is more in depth on the very next line. He’s asking this question out of guilt — not questioning if what the bible says is true — but now that he’s this “evil” person; is he still considered a man in God’s image? Is he worthy to be in God’s image after the sins committed? This connects to the “Born Sinner” title and theme of the album.

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