I slurped too many pain-kills, down I'm off a lot
I got a lot off days but it ain't often that I'm off the clock

from Chance The Rapper (Ft. BJ The Chicago Kid & Saba) – Everybody's Something Lyrics on Rap Genius

Meaning

Chance is saying here that leading up to this point in his life, he has consumed a fair amount of painkilling drugs, leaving him frequently feeling a bit “off”. If you’ve taken drugs routinely yourself then you probably know this kind of mentality and thought process.

He’s got a lot of days where he is feeling off, but he’s always working on music, regardless of how he feels. It’s how he creates the best.

With the “off days” part, it could be a reference to a song off 10 Day called “22 Offs”, while the line before echos “Brain Cells”:

I burned too many brain cells down to be worried bout my brain cells now

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