There's no one inside
But you're free to relax
These lines can be interpreted in different ways. One meaning could be that he’s referring to himself and his rise to mainstream fame when he says “there’s no one inside” the mainstream RnB circle who is of the same caliber as his.
The Weeknd is a unique artist. There’s truly no other artist right now who makes the kind of music Abel makes and is as successful at it as he is.
Another interpretation could be that he’s inviting this particular female into his world (or literally, his house) and telling her to feel comfortable and assuring her that there’s no one other than her who has Abel’s attention right now. No one is more relaxed than when they know no one else is home.
Besides the obvious sexual encounter the song narrates. This entire song can also be interpreted as Abel conversing with himself—maybe with his ego on drugs, during sex, as a result of fame, etc.
At this point it could be his drugged ego talking to his nonexistent ‘self’. “There’s no one inside” because he has distorted himself so much with drugs, but without that self, his mind is finally at ease. This is also reflected in the last verse when he says “But I’m always getting high / Cause my confidence is low.” He is escaping self.
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