When your thoughts can't breathe and you thinking asthmatic

from Childish Gambino (Ft. Lloyd) – III. Telegraph Ave. ("Oakland" by Lloyd) Lyrics on Rap Genius

Meaning

Pretty much just nothing going up there. Especially when you deprive your brain of oxygen your thought process is the first thing to go. In reference in to the next line, Childish is feeling suffocated by being with someone but they have differing intentions.

This line may be a suggesting an orgasm. Her thoughts being more primal like getting off and procreation and that stuff.

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