Don't mess with us, we like the U in the 80's
Back to back, set a trap, hit the lick, hit it back

from DJ Khaled (Ft. Ludacris, Rick Ross, Snoop Dogg & T-Pain) – All I Do Is Win Lyrics on Rap Genius

Meaning

“The U” is The University of Miami, specifically the football team.
In the 1980’s they were a NCAA Football powerhouse, although they never actually won “back-to-back” National Championships as Snoop says.

They won in 1987 and 1989 and believed they were robbed in 1988. They were also a notoriously “tough team” who fought and bullied other teams to the point that Notre Dame refused to schedule any further games against them.

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