Things done changed on this side
Remember they used to thump but now they blast, right

from Dr. Dre (Ft. Dat Nigga Daz & Snoop Dogg) – Lil' Ghetto Boy Lyrics on Rap Genius

These times they are a-changin'

Dre remembers when people used to fight back in the days, now they use guns and don’t fight man to man.

Aside from the obvious, and to acknowledge yet another influence this album had on the hip hop world, this line was used as the hook on The Notorious B.I.G.’s “Things Done Changed” on Ready to Die.
http://www.youtube.com/watch?v=rdciOXroU9o

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