And my nigga Biggie got a itchy one grip

from The Notorious B.I.G. – Gimme The Loot Lyrics on Rap Genius

Meaning

The index finger is used to signify the number 1 and also to pull the trigger of a gun. Holding a gun with the index finger on the trigger could be called a “one grip”

Someone with an “itchy” trigger finger is eager to fire his weapon

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