I pray to the Lord the Cowboys win
And beat the hell outta them damn Redskins

from Macklemore – American Lyrics on Rap Genius

Meaning

It’s a reference to the Dallas Cowboys beating their rival the Washington Redskins since the Cowboys are “America’s Team”

He is likely from Texas, as he is a Cowboys fan. Football is immensely popular in the regions of the country where the views described in this song are most popular.

This also serves as a metaphor for Western Expansion, or Manifest Destiny. No one cared about the Native Americans (redskins) who already lived here, and during the times of cowboys and the Wild West the men who did battle with the natives were seen as heroes. Settlers encouraged this “vengeance” against the “savages”, who’s land they were in fact invading and taking. No one was persecuted for killing a Native American.

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