Dismissed, feel it in that saturated cranium
Earl’s head (“cranium”) is so full of knowledge that it could be considered “saturated”.
He feels the “lit spliff” from the previous line starting to take effect.
Earl after smoking the spliff (mixture of tobacco and weed,blunts are sometimes called this) is dismissed (not really there, his mind his elsewhere). Feel it in that saturated cranium refers to the feeling you get when you get very high off some psychoactive sativa dominant strains like OG kush that will make your head feel full and fuzzy.
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