You full of shit, you close your mouth and let yo' ass talk

from Lil Wayne (Ft. Cory Gunz) – 6 Foot 7 Foot Lyrics on Rap Genius

Meaning

Being “full of shit” and “talking out of your ass” are both expressions for the same thing — lying/embellishing

Since Weezy loves poop puns, he makes the easy connection

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