Merge the mixture with the purest and the fruits
And the thirst, just the worst, it's the curse of the juice!

from Chance The Rapper (Ft. Kembe X) – JUICE Lyrics on Rap Genius

Meaning

Chance is referring about the whole song itself. It’s a mixture of his pure intent and his exotic taste in music AKA the fruit. The last line is a comparison to this song again, just like when you drink really good juice you get thirsty after a while and want to drink the juice again, once you hear this song you literally want to listen to Juice again!

Its also saying girls/people/haters in general are thirsty when you have the “JUICE” meaning the power, fame, limelight, etc. Not to mention the obvious reference to the film, on how once the main character kills he keeps doing it more until he finally dies.

https://www.youtube.com/watch?v=V08PFn8Att8

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