From nice to deadly like a bad bag of D

from Jay Z – Cashmere Thoughts Lyrics on Rap Genius

Meaning

“D” normally means drugs, dope — heroin to be specific: whereas you may get your hopes up that your trip is going to be awesome, if the drugs are tainted you’ll have a terrible time or possibly die

Most likely Heroin, a bad bag is a hot shot which will kill
Your ass

Following the preceding lines, Jay continues with this prolonged sexual innuendo throughout the entire verse; Sexual activity could be a thrill until it turns deadly, possibly STD’s. A bad bag of ’D' is a reference to dick(penis)… a broken condom(bag) exposes you to any and every disease or reason you used the condom in the first place.

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