Pussy had me dead
Might call 2Pac over

from Kanye West (Ft. Chief Keef & Justin Vernon) – Hold My Liquor Lyrics on Rap Genius

Meaning

This girl’s sex game makes ‘Ye feels so good, it’s like he’s died and gone to heaven. Ye’s calling 2Pac to hang out with him in heaven.

We also see the ongoing dichotomy between the Good & Bad, the inner battle and positive and negative imagery within the song. In one instance, Kanye describes sex as nearly spiritual, enlightening him to an elevated state, while in the next, it has caused his death. This interpretation ties back into the sense of regret over Phifer, and the amount of time he spent mourning the loss of his relationship with her.
At the same time, sex has driven Kanye into his dark being, allowing the reality presented by Chief Keef (Not handling his liquor) to overcome him and drive him into an increasingly isolated and self-destructive state.

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