I can hold my liquor
But this man can’t handle his weed

from Kanye West (Ft. Chief Keef & Justin Vernon) – Hold My Liquor Lyrics on Rap Genius

Meaning

When Vernon says “this man can’t handle his weed”, “this man” that he is talking about is actually Chief Keef and his version of the hook. Vernon’s hook is blurry and distorted, so it is trying to represent the effects of alcohol. And Chief Keef’s hook is displaying the effects of weed, as you can actually hear Chief Keef inhaling and exhaling smoke right before he starts his hook. Since both versions come from Kanye’s point of view, this “argument” demonstrates his inner turmoil. There’s a side of Kanye that is over-the-top cocky, but also a “dark and lonely” side that makes him feel worthless.

These two hooks are Kanye’s version of a devil and an angel on his shoulders fighting for control, since the messages both contradict themselves. Vernon’s hook shows Kanye trying to convince himself that he is awesome, even though he knows deep down that he’s just a lonely loser. And Chief Keef’s hook is Kanye beating himself up, even though in this version he thinks that deep down he is awesome and god-like.

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