How can I reel-to-reel when there's Pro Tool?
Lupe’s conveying the sentiment that he misses that old school sound, an idea that’s further stated in the track’s artwork of a tape cassette. He is also saying he finds it difficult to be real-to-real (straight up) with machinery and computerised tech which allows for many synthetic sounds/effects.
Lastly, Lupe is asking how he can keep it honest in the rap-game when everyone else is pro-tool (meaning they are pro-gun and pro-violence).
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